PomBioTech - Experts in drug metabolite production

PomBioTech has specialized on the production of drug metabolites synthesized by human cytochromes P450 and human UDP-glucuronosyltransferases (UGT). Using recombinant fission yeast strains (Schizosaccharomyces pombe) we are able to biotechnologically produce custom made metabolites including cytochrome P450 and UGT metabolites (glucuronides) up to technical scale (mg to 100 g range). In addition to this we offer a variety of glucuronides and cytochrome P450 metabolites for use as reference standards (e.g. for LC/MS and LC/MS-MS). All reference standards can also be labeled with either deuterium or 13C. Besides this, PomBioTech also offers the generation of custom made fission yeast strains for the production of biosimilars or other proteins as well as the subsequent industrial production process development (up to 50L fermentation and down-stream processing).

S. pombe cells expressing GFP and cytochrome P450 computer model

When dealing with proteins that are difficult to express functionally in microbes (e.g. E. coli) or other yeasts fission yeast has in many instances turned out to be a suited model system in our hands.
In addition to these CRO activities, PomBioTech has a dedicated in-house R&D department which focuses on the development of new technology platforms.

If you are looking for drug metabolites or are interested in
custom made fission yeast strains don't hesitate to contact us!